1000+ Studies · 7000+ Comparisons · 3 Species
TxPerturb-DB
Transcriptome Perturbation Database — Explore small molecule effects on gene expression across dose and time gradients in human, mouse, and rat.
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Analysis Tools
Powerful computational tools for drug repurposing and transcriptomic analysis
CMap Scoring
Signature Search
Upload a gene expression signature (up/down-regulated gene lists) and find compounds that reverse or mimic your profile using Connectivity Map-style scoring.
Dose × Time
Gradient Explorer
Visualize transcriptomic effects across dose and time gradients. Identify inflection points and optimal perturbation conditions for any compound.
3 Species
Cross-Species Comparison
Compare transcriptomic responses of the same compound across human, mouse, and rat via ortholog mapping. Assess translational potential for drug candidates.